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. 2021 Apr 12;22(8):3979. doi: 10.3390/ijms22083979

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Alignment of LeishIF4E-5 from L. amazonensis with its protozoan orthologs, with eIF4E-1 from mammals, with yeast eIF4E and C. elegans IFE-3. The alignment includes sequences of LeishIF4E-5 from Leishmania amazonensis (L_ama_IF4E5), Trypanosoma brucei (T_bru_IF4E5), Crithidia fasciculata (C_fas_IF4E5) and Leptomonas seymouri (L_sey_IF4E5). It also includes the sequences of the canonical eIF4E from Homo sapiens (H_sap_IF4E-1), Mus musculus (M_mus_IF4E-1) and Saccharomyces cerevisiae (S_cer_IF4E5) along with IFE-3 from C. elegans (C_ele_IFE3) and P. falciparum (P_fal_IF4E). All sequences were subjected to multiple sequence alignment to highlight their homologies. Conserved tryptophan residues involved in cap-binding are marked with asterisks. The multiple sequence alignment was performed using MAFFT, version 7. Sequence conservations were generated by Jalview and are highlighted in greyscale.