Table 3.

BRO-CD44 relationship.

Year/Ref	Tissue	Findings
1992 [144]	Human T cells	BRO removed CD44 from the cell surface
1994 [145]	Human peripheral blood lymphocytes	BRO reduced the CD44 mediated adhesion of human lymphocytes to human umbilical vein endothelial cells.
1994 [126]	Leukemia and melanoma cells	BRO modulated CD44 expression
1996 [146]	Lymphocytes	BRO modulated CD44 expression and reduced lymphocyte adhesiveness.
2001 [129]	Glioma cells	BRO reduced invasiveness of glioblastoma cells by downregulating CD44
2016 [147]	Human and mouse tumor cells	BRO reduced CD44 expression from the surface of tumor cells.