Figure 2.

Inhibitory effect of compound 15 on Ca²⁺ mobilization and ROS production in human neutrophils. (A) Human neutrophils were treated with the indicated concentrations of compound 15 or 1% DMSO (negative control) for 10 min. The cells were activated by 5 nM fMLF, and [Ca²⁺]_i was monitored, as described. (B) Human neutrophils were treated with the indicated concentrations of compound 15 or 1% DMSO (negative control) for 10 min. The cells were activated by 200 nM PMA, and ROS production was monitored, as described. For each panel, the data are presented as the mean ± S.D. (N = 3) from one experiment that is representative of three independent experiments.