Table 1.

Effect of aza- and diaza-crown ethers on [Ca²⁺]_i flux in human neutrophils.

Compound	EC50 (µM) (Efficacy, %)
5	N.A.
6	N.A.
7	N.A.
8	22.4 ± 4.3 (50)
9	N.A.
10	9.7 ± 2.6 (35)
11	15.6 ± 4.4 (40)
12	23.8 ± 7.6 (25)
13	6.9 ± 2.1 (25)
14	9.5 ± 2.7 (40)
15	4.7 ± 1.5 (110)
16	15.7 ± 3.8 (25)
17	15.9 ± 2.5 (50)
18	N.A.
19	N.A.
20	N.A.
21	11.3 ± 3.1 (40)
22	N.A.
23	N.A.
24	N.A.
25	N.A.
26	N.A.
27	N.A.
28	N.A.

N.A., no activity was found at concentration < 50 µM. Efficacy (in parentheses) is expressed as % of the response induced by 5 nM fMLF.