BL2	blocking loop 2
COVID-19	coronavirus disease 2019
DUB	deubiquitinating enzyme
EF	enrichment factor
HBA	hydrogen bond acceptor
HBD	hydrogen bond donor
HCV	hepatitis C virus
HIV	human immunodeficiency virus
IC50	half maximal inhibitory concentration
ISG	interferon-stimulated gene
ISG15	interferon-stimulated gene 15
LD50	lethal dose, 50%
MERS-CoV	Middle East respiratory syndrome coronavirus
MLR	multiple linear regression
MM–GBSA	molecular mechanics—generalized Born and surface area solvation
Mpro	main protease
MW	molecular weight
PDB	Protein Data Bank
PLpro	papain-like protease
QSAR	quantitative structure–activity relationship
RMSD	root-mean-square deviation
SARS-CoV	severe acute respiratory syndrome coronavirus
SARS-CoV-2	severe acute respiratory syndrome coronavirus 2
SP	standard precision
TEST	Toxicity Estimation Software Tool
TPSA	topological polar surface area
Ub	ubiquitin
Ubl	ubiquitin-like (domain)
UbVMe	ubiquitin-vinyl methyl ester
UCH-L1	ubiquitin carboxy-terminal hydrolase L1
UCH-L3	ubiquitin carboxy-terminal hydrolase L3
WHO	World Health Organization
XP	extra precision