Table 3.
Examples of clinical trials with adenoviruses.
| Virus | Transgene | Combination | Tumor Type | Phase | Status | Reference |
|---|---|---|---|---|---|---|
| LOAd703 | CD40L, 4-1BBL |
None | Pancreatic cancer, ovarian cancer, biliary carcinoma, colorectal cancer | 1 & 2 | Recruiting | NCT03225989 |
| LOAd703 | CD40L, 4-1BBL |
atezolizumab | Malignant Melanoma | 1 & 2 | Recruiting | NCT04123470 |
| LOAd703 | CD40L, 4-1BBL |
Gemcitabine, nab-paclitaxel and atezolizumab | Pancreatic cancer | 1 & 2 | Recruiting | NCT02705196 |
| TILT-123 | hIL-2, TNFa |
None | Metaststic melanoma | 1 | Recruiting | NCT04217473 |
| DNX-2440 | OX40L | None | Glioblastoma | 1 | Recruiting | NCT03714334 |
| CG0070 | GM-CSF | None | Bladder cancer | 2 | Completed | NCT02365818 |
| Delta-24-RGD | None | None | Brain tumor | 1 & 2 | Completed | NCT01582516 |
| MG1-MAGEA3 | MAGEA3 | Pembrolizumab, Ad-MAGEA3 |
NSCLC | 1 & 2 | Completed | NCT02879760 |