Table 2.

The list of common driver genes identified by NICD.

Common Gene	Dementia Genes	Osa Genes	Olfactory	GPCR	p Value
TMEM181	SH3RF1	NRG1			1.36 × 10−4
TSPAN19	TSPAN16	TSPAN18			8.31 × 10−6
CSTL1	AHSG, PRKN	NRG1			4.93 × 10−4
RNF121	ITGB2	LPAR1			2.60 × 10−4
AL121594.3	RNF4	NRG1			5.04 × 10−4
OR4E2	MC1R	ARRB1	✓	✓	5.15 × 10−4
FAM241A	PLP1, LINGO1	LPAR1, SGCD			2.35 × 10−4
FITM2	CCRL2, HTR2C	LPAR1, TSPAN18			2.74 × 10−4
OR2L13	ZP3	ARRB1	✓	✓	2.02 × 10−4
OR11H4	PTAFR	ARRB1	✓		2.13 × 10−4
CST11	CST3, AHSG	NRG1			3.43 × 10−4
OR4C6	HEATR4	ARRB1	✓	✓	2.71 × 10−4
TMEM120A	VKORC1	TSPAN18			2.47 × 10−4
OR2AE1	PTAFR, GPR65	ARRB1	✓	✓	4.74 × 10−4
OR7C1	CHRM1	ARRB1	✓	✓	3.63 × 10−4
TMEM87B	SLC30A7	LPAR1			1.91 × 10−4
OR8D1	CBLL2, ADAD1	ARRB1	✓	✓	2.88 × 10−4
OR4S2	ADAM10	ARRB1	✓	✓	3.57 × 10−4
OR2J2	PCDH11X	ARRB1	✓	✓	5.26 × 10−4
TMED8	TMED9	PTGER3			1.22 × 10−4
OR2C3	CBLL2, ADAD1, CCDC62	ARRB1			4.16 × 10−4
TMCO5A	DKKL1, TEX33, ADAD1, CCDC62, CBLL2	TSPAN18			3.38 × 10−4
HSPA7	UBXN11	ARRB1			2.27 × 10−4
ZSWIM9	ESR2, ZNF292	AHDC1			5.15 × 10−4
FABP9	FABP2	FABP4			6.09 × 10−5
GTSF1	HSPB1	MPHOSPH6			1.47 × 10−4
TMEM151A	CAMK2A, SNCB	LPAR1			5.60 × 10−4
TMEM218	NARS2	TSPAN18			3.99 × 10−4
MGAT5B	FAM171A2, MGAT5	PTGER3			2.44 × 10−4
OR6F1	PTAFR	ARRB1	✓	✓	2.13 × 10−4
ZNF385D	ZNF804A	PTGER3			4.71 × 10−5
TMEM161B	RPS6KB1	LPAR1			1.63 × 10−4
LARGE2	DKKL1	NRG1			4.13 × 10−4
SCFD2	SCFD1, STXBP2, UBE2Z, SIRT2	NBAS			2.83 × 10−4
RAVER2	CNKSR3	NRG1			2.94 × 10−4
CPNE8	TRPM1, VAMP8, NDUFS1, SOAT1	ARRB1			5.29 × 10−4
ARRDC2	RXRA, PDE4D	ARRB1			4.68 × 10−4
OLFM2	TUBB1	NBAS			3.55 × 10−4
ENOX1	NOX4, SETD1A, RBMS3	LPAR1			5.76 × 10−4
TMEM120B	RNF5, SIGMAR1	LPAR1			4.32 × 10−4
BLOC1S3	DTNBP1, DNAJC6	ARRB1			2.63 × 10−4
CFAP45	SPTAN1, PACRG	ARRB1			4.13 × 10−4