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Simplified schematic representation of the tumor microenvironment. (A) Schematic representation of immune cells in tumor microenvironment that have an anti-tumorigenic effect (natural killer and tumor-infiltrating lymphocytes) and of other tumor-infiltrating immune cells that have a pro-tumorigenic effect (CD4+ T helper lymphocytes 2 (Th2), the regulatory CD4+ T-lymphocytes (Treg)). (B) schematic representation of immune cells role in tumor spreading process.
