Table 2.
Overview of the approved liposomes in EU and US.
| Initial Approval Time | Commercial Name | Drug | Liposome Components | Treatment |
|---|---|---|---|---|
| 1995 | Doxil® | Doxorubicin | HSPC: cholesterol: DSPE-PEG [6] |
Breast neoplasms; multiple myeloma; ovarian neoplasms; Kaposi’s sarcoma |
| 1995 | Abelcet® | Amphotericin B | DMPC:DMPG [6] | Life-threatening fungal infections. |
| 1996 | DaunoXome® | Daunorubicin | DSPC: Cholesterol [6] | Cancer advanced HIV-associated Kaposi’s sarcoma |
| 1997 | AmBisome® | Amphotericin B | HSPC:DSPG, cholesterol [6] | Visceral leishmaniasis |
| 1999 | DepoCyt® | Cytarabine | DOPC:DPPG [6] | Neoplastic meningitis |
| 1999 | Curosurf® | SP-B and SP-C | A natural surfactant of porcine lungs [6] | RDS in premature infants |
| 2000 | AmBisome® | Amphotericin B | HSPC:DSPG, cholesterol [6] | Cryptococcal Meningitis in AIDS Patients |
| 2000 | Myocet® | Doxorubicin | EPC: Cholesterol | Breast neoplasms |
| 2000 | Visudyne® | Verteporfin | EPG:DMPC [6] | Sub foveal choroidal neovascularization |
| 2004 | DepoDur® | Morphine | DOPC:DPPG [6] | Pain relief |
| 2009 | Marqibo® | Vincristine | SPH: Cholesterol [6] | Philadelphia chromosome-negative acute lymphoblastic leukemia [6] |
| 2009 | Mepact® | Mifamurtide | DOPC:DOPS [6] | Osteosarcoma |
| 2011 | Exparel® | Bupivacaine | DEPC: DPPG: Cholesterol: Tricaprylin [6] |
Anesthetic |
| 2012 | Marqibo® | Vincristine | SPH: Cholesterol [6] | Hematologic malignancies and solid tumors [7,71] |
| 2013 | Lipodox® | Doxorubicin | HSPC: Cholesterol: DSPE-PEG [6] |
Breast neoplasms |
| 2015 | Onivyde® | Irinotecan | DSPC: Cholesterol: DSPE-PEG [6] |
Metastatic pancreatic cancer |
| 2017 | Liposomal doxorubicin | Doxorubicin | HSPC: Cholesterol: DSPE-PEG [6] | Breast neoplasms |
| 2017 | Nocita® | Bupivacaine | DEPC: DPPG: Cholesterol: Tricaprylin [6] |
Anesthetic |
| 2017 | Vyxeos® (CPX-351) |
Daunorubicin Cytarabine | DSPC: DSPG: Cholesterol [6] |
Acute myeloid leukemia |
| 2018 | ArikayceTM | Amikacin | DPPC: Cholesterol [6] | Mycobacterium avium complex lung disease |
| 2018 | LipoplatinTM NanoplatinTM |
Cisplatin | DPPG: soy PC: MPEG-DSPE: Cholesterol [72] | Pancreatic cancer Lung cancer |