Table 3.
LncRNA GAS5 in OP and OS.
| Disease | Sources | Pattern Expression Profile | Regulation Mechanism | Related Effects | Study |
|---|---|---|---|---|---|
| OS | Tissues and cells | ↓ | Sponging miR-23a-3p (PTEN/PI3K/AKT) | Regulates OS cell proliferation and invasion | [86] |
| OS | Cells | ↓ | Sponging miR-203a (TIMP2) | Regulates OS cell growth and metastasis | [87] |
| OS | Tissues and cells | ↓ | Sponging miR-221 (ARHI) | Regulates OS cell growth and EMT | [88] |
| OS | Tissues and cells | ↓ | Sponging miR-663a (RHOB) | Regulates OS progression | [89] |
| OS | Tissues and cells | ↓ | Sponging miR-663a (MYL9) | Regulates OS progression | [90] |
| OP | Tissues, cells, and animals | ↓ | Regulation of UPF1/SMAD7 axis | Regulates osteoblast differentiation | [91] |
| OP | Cells | ↓ | Sponging miR-498 (RUNX2) | Regulates osteogenic differentiation | [93] |
| OP | Serum | ↑ | / | / | [94] |
| OP | Plasma | ↑ | Downregulation of miR-21 | Regulates apoptosis of osteoclasts | [95] |