Table 5.
LncRNA MALAT1 in OS, ES, and OP.
| Disease | Sources | Pattern Expression Profile | Regulation Mechanism | Related Effects | Study |
|---|---|---|---|---|---|
| OS | Tissues and, cells | ↑ | Sponging miR-26a-5p (FOXO1) | Mediates OS cells proliferation and migration | [117] |
| OS | Tissues and cells | ↑ | Sponging miR-34a (CCND1) | Promotes OS progression | [118] |
| OS | Tissues, cells, and animals | ↑ | Sponging miR-202 | Facilitates lung metastasis of OS | [119] |
| OS | Tissues, cells, and animals | ↑ | Sponging miR-129-5p (RET-Akt pathway) | Promotes OS metastasis | [120] |
| OS | Tissues, cells, and animals | ↑ | Sponging mir-144-3p (ROCK1/ROCK2) | Promotes OS cells metastasis and proliferation | [121] |
| OS | Tissues and cells | ↑ | Sponging miR-205 (SMAD4) | Promotes OS cells proliferation | [122] |
| OS | Tissues and cells | ↑ | Sponging miR-140-5p (HDAC4) | Regulates OS cells proliferation and apoptosis | [123] |
| OS | Tissues and cells | ↑ | Sponging miR-142-3p and miR-129-5p (HMGB1) | Promotes OS development | [124] |
| OS | Tissues and cells | ↑ | Sponging miR-376a (TGFA) | Promotes OS development | [125] |
| OS | Tissues and cells | ↑ | Sponging miR-129-5p (TGIF2) | Promotes proliferation, migration, and invasion of OS cells | [126] |
| OS | Tissues, cells, and animals | ↑ | Sponging miR-509 (Rac1/JNK Pathway) | Promotes the proliferation and metastasis of OS Cells | [127] |
| OS | Tissues and cells | ↑ | Regulating RhoA/ROCK pathway | Promotes OS development | [128] |
| OS | Tissues, cells, and animals | ↑ | Regulating E-cadherin and β-catenin expression | Supports OS metastasis | [129,130] |
| OS | Tissues and cell | ↑ | Regulating of PI3K/AKT signaling pathway | Regulates proliferation and metastasis of OS | [131] |
| OS | Cells and animals | ↑ | Regulating mTOR and HIF-1α | Induces pro-angiogenic effects in OS | [132] |
| ES | Cells and animals | ↑ | Regulated by SYK/cMYC | Contributes to the ES malignancy | [133] |
| ES | Cells and animals | ↑ | Regulated by TNC/Integrin α5β1/YAP axis | Regulates ES progression | [134] |
| OP | Bioinformatic studies | / | Regulating miR-22-3p-PTEN/ESR1/ERBB3/CSF1R/CDK6 and miR-32-3p-SP1/FZD6 axis | Possible role in OP biology | [135] |
| OP | Cells and animals | ↓ | Promoting the activation of the MAPK signaling pathway | Contributes to the OS onset and progression | [136] |
| OP | Cells and animals | ↑ | Sponging miR-34c (SATB2) | Mitigates the symptoms of OP | [137] |