| Major in vivo modeling approaches | |
| CDX | Cell-line-derived xenograft |
| EIMM | Environmentally-induced mouse model |
| GEMM | Genetically-engineered mouse model |
| PDOX | Patient-derived orthotopic xenograft |
| PDX | Patient-derived xenograft |
| Focus sarcoma entities of this review with abbreviations and typical drivers | |
| aRMS | Alveolar Rhabdomyosarcoma (PAX3/7-FOXO1) |
| ASPS | Alveolar soft part sarcoma (ASPSCR1-TFE3) |
| CCS | Clear cell sarcoma (of soft tissue) (EWSR1-ATF1) |
| CCSK | Clear cell sarcoma of the kidney (BCOR ITDs, YWAHE-NUTM2) |
| DSRCT | Desmoplastic small round cell tumor (EWSR1-WT1) |
| eRMS | Embryonal Rhabdomyosarcoma (KRAS and TP53 alterations among various others) |
| EwS | Ewing Sarcoma (EWSR1-FLI1, EWSR1-ERG, STAG2) |
| IFS | Infantile fibrosarcoma (ETV6-NTRK3) |
| IMT | Inflammatory myofibroblastic tumor (ALK fusions, among others) |
| MC | Mesenchymal chondrosarcoma (HEY1-NCOA2) |
| MPNST | Malignant peripheral nerve sheath tumor (NF1 and TP53 deletions) |
| MRT | Malignant rhabdoid tumor (SMARCB1) |
| MYOD1-RMS | MYOD-mutated (typically spindle cell) rhabdomyosarcoma (MYOD-hotspot mutation among others) |
| OS | Osteosarcoma (TP53, SNVs) |
| SRBCT | Small round blue cell tumors, previously called Ewing-like tumors, subgroups harboring BCOR- and CIC rearrangements |
| SySa | Synovial Sarcoma (SS18-SSX1/2/4) |
| UPS | Undifferentiated pleomorphic sarcoma, previously called Malignant fibrous histiocytoma (KRAS and TP53 among various others) |