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. 2021 Apr 8;10(8):1578. doi: 10.3390/jcm10081578
Major in vivo modeling approaches
CDX Cell-line-derived xenograft
EIMM Environmentally-induced mouse model
GEMM Genetically-engineered mouse model
PDOX Patient-derived orthotopic xenograft
PDX Patient-derived xenograft
Focus sarcoma entities of this review with abbreviations and typical drivers
aRMS Alveolar Rhabdomyosarcoma (PAX3/7-FOXO1)
ASPS Alveolar soft part sarcoma (ASPSCR1-TFE3)
CCS Clear cell sarcoma (of soft tissue) (EWSR1-ATF1)
CCSK Clear cell sarcoma of the kidney (BCOR ITDs, YWAHE-NUTM2)
DSRCT Desmoplastic small round cell tumor (EWSR1-WT1)
eRMS Embryonal Rhabdomyosarcoma (KRAS and TP53 alterations among various others)
EwS Ewing Sarcoma (EWSR1-FLI1, EWSR1-ERG, STAG2)
IFS Infantile fibrosarcoma (ETV6-NTRK3)
IMT Inflammatory myofibroblastic tumor (ALK fusions, among others)
MC Mesenchymal chondrosarcoma (HEY1-NCOA2)
MPNST Malignant peripheral nerve sheath tumor (NF1 and TP53 deletions)
MRT Malignant rhabdoid tumor (SMARCB1)
MYOD1-RMS MYOD-mutated (typically spindle cell) rhabdomyosarcoma (MYOD-hotspot mutation among others)
OS Osteosarcoma (TP53, SNVs)
SRBCT Small round blue cell tumors, previously called Ewing-like tumors, subgroups harboring BCOR- and CIC rearrangements
SySa Synovial Sarcoma (SS18-SSX1/2/4)
UPS Undifferentiated pleomorphic sarcoma, previously called Malignant fibrous histiocytoma (KRAS and TP53 among various others)