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Pleiotropic roles of Stromal cell-derived factor-1α (SDF-1α)/C-X-C chemokine receptor type 4 (CXCR4) axis in multiple myeloma cells. SDF-1α/CXCR4 axis plays pleiotropic roles in multiple myeloma (MM) pathogenesis including proliferation, survival, migration, homing, drug resistance, epithelial-mesenchymal transition (EMT), dissemination, and extramedullary disease (EMD) formation.
