Table 1.

Overview of some compounds targeting SDF-1α/CXCR4 axis in MM cells.

Compound	Mechanism of Action	References
Plerixafor	CXCR4 antagonist Inhibits migration and homing of MM cells	[101]
Ulocuplumab	CXCR4 antagonist Induces apoptosis in MM cells with high CXCR4 expression Inhibits SDF-1α-induced migration	[102,103]
F50067	CXCR4 antagonist Inhibits cell migration and proliferation Antibody-dependent cellular cytotoxicity Compliment-dependent cytotoxicity	[104]
177Lu- and 90Y-pentixather	CXCR4-directed endoradiotherapeutic agent	[108]
Olaptesed pegol	SDF-1 inihibitor Neutralizes SDF-1 Inhibits colonization and dissemination of MM cells	[110,111]