Table 2.
Description of the markers considered and their relationship with the occurrence of metastasis.
| Biomarker | Non Metastatic N = 96, Mean ± SD | Metastatic N = 91, Mean ± SD | MR * | 95% CI | p |
|---|---|---|---|---|---|
| AR | |||||
| cytoplasm | 14.4 (20.1) | 17.5 (19.7) | 1.55 | 0.87–2.73 | 0.134 |
| epithelium | 3.3 (6.7) | 5.7 (10.8) | 1.44 | 0.97–2.12 | 0.070 |
| stroma | 1.8 (4.5) | 4.5 (8.9) | 1.48 | 1.01–2.18 | 0.047 |
| ki67 | |||||
| epithelium | 45.9 (14.7) | 50.1 (15.4) | 1.10 | 1.01–1.21 | 0.041 |
| stroma | 14.3 (7.5) | 12.2 (8.2) | 0.78 | 0.64–0.95 | 0.013 |
| HF1beta | |||||
| epithelium | 26.6 (29.1) | 14.3 (21.6) | 0.37 | 0.21–0.65 | 0.001 |
| stroma | 11.0 (19.2) | 6.4 (14.9) | 0.93 | 0.57–1.51 | 0.760 |
| VEGF | |||||
| epithelium | 15.5 (17.4) | 9.6 (15.1) | 0.48 | 0.29–0.80 | 0.005 |
| stroma | 16.5 (22.0) | 9.5 (12.8) | 0.57 | 0.34–0.97 | 0.036 |
| macrophages | 15.7 (22.4) | 5.5 (9.7) | 0.41 | 0.24–0.69 | 0.001 |
| lymphocytes | 0.8 (4.4) | 3.8 (10.4) | 1.49 | 1.07–2.08 | 0.019 |
| MMP9 | |||||
| epithelium | 18.9 (23.4) | 15.2 (25.7) | 0.54 | 0.30–0.98 | 0.044 |
| stroma | 39.1 (22.1) | 43.6 (25.0) | 1.22 | 0.88–1.69 | 0.240 |
| macrophages | 11.3 (15.5) | 15.4 (14.2) | 2.43 | 1.45–4.06 | 0.001 |
| lymphocytes | 27.5 (24.7) | 29.3 (24.7) | 1.17 | 0.58–2.33 | 0.662 |
* adjusted by age and gender; p-value < 0.05 (presented on bold) considered statistically significant.