Table 1.

The effect of antioxidant supplementation on obesity caused by oxidative stress (OS).

Reference	Subjects	Antioxidant Supplementation	Results
Simán et al. [102]	Sprague Dawley rats	BHT (0.5% and 1%) with or without vitamin E acetate (4%) for four weeks.	No change in the alpha-tocopherol concentration of abdominal AT with BHT supplementation.
Rodrigues et al. [103]	FVB/n male 7-month-old mice	Chestnut at a dose of 1.1%.	The reduction of serum cholesterol and AT deposition.
Candiracci et al. [29]	Obese and lean Zucker rats	Rice bran enzymatic extract (RBEE) for 20 weeks.	The reduction of overproduction of IL-6, TNF-α, IL-1β, and NOS in abdominal and epidermal visceral AT. Reducing the adipocyte size of abdominal and epidural visceral AT.
Valls et al. [104]	Male Wistar rats	Diet rich in corn oil with or without antioxidant supplementation of vitamin E (30 mg per day).	The reduction of activity of the antioxidant enzymes CAT and SOD.
Arias et al. [105]	Male Wistar rats	Quercetin (30 mg/kg body weight).	No impact on reducing AT size and body weight. No change in the activity of lipoprotein lipase and lipogenic enzymes.
Chen et al. [106]	Syrian male Golden Hamsters	Protease A-digested crude-chalaza hydrolysates (CCH-As).	The reduction adipose-perinatal/hepatic tissue size. The increase of lipolysis (unpaired carnitine palmitoyltransferase 1, hormone-sensitive lipase, and protein 2).
Djurasevic et al. [107]	Male Wistar rats	Vitamin C supplementation (low and high doses of 0.75 and 25 mg of ascorbic acid per kg of body weight, respectively) for 4 weeks.	Excessive consumption of this antioxidant supplement was able to strengthen antioxidant defenses (MnSOD, CuZnSOD, and CAT in AT
Sung et al. [108]	Male C57BL/6J mice	High-fat diet or a high-fat diet with PAE at a dose of 400 mg/kg body weight per day.	The reduction of AT weight, serum TG concentration, body weight, MDA and leptin concentrations, and fat cell area.
Alcalá et al. [30]	C57BL/6J mice	Vitamin E supplementation (150 mg twice daily).	The reduction in collagen deposition and OS in rat visceral AT. The increase of storage capacity and fat cells’ proliferation.