Table 2.
Assessment of the effect of red clover isoflavones on the frequency of hot flushes in subgroup analysis.
| Variables | n | Simple Size | WMD (95% CI) | p | I2 (%) |
|---|---|---|---|---|---|
| Overall effects | 10 | 751 | −1.73 (−3.28, −0.18) | 0.0292 | 87.34 |
| Menopausal status | |||||
| Postmenopausal | 7 | 315 | −2.68 (−4.72, −0.63) | 0.0105 | 71.44 |
| Peri- and post-menopausal | 3 | 436 | 0.01 (−0.55, 0.58) | 0.9594 | 0.00 |
| Follow-up period | |||||
| 12 weeks | 9 | 652 | −1.95 (−3.61, −0.30) | 0.0206 | 81.33 |
| 12 months | 1 | 99 | 0.20 (−0.58, 0.98) | 0.6149 | (-) |
| Frequency of hot flushes | |||||
| ≥5/day | 6 | 552 | −2.56 (−4.49, −0.62) | 0.0096 | 87.67 |
| ≥3/day | 4 | 199 | 0.21 (−0.53, 0.96) | 0.5761 | 0.00 |
| Isoflavones dose | |||||
| <80 mg/day | 6 | 431 | −0.88 (−2.34, 0.58) | 0.2370 | 76.83 |
| ≥80 mg/day | 4 | 320 | −2.80 (−6.35, 0.74) | 0.1210 | 86.61 |
| Dominant of isoflavones | |||||
| Biochanin A | 8 | 524 | −1.79 (−3.60, 0.02) | 0.0520 | 85.78 |
| Formononetin | 2 | 227 | −1.14 (−4.13, 1.84) | 0.4519 | 73.64 |
n, number of comparisons; -, not calculated.