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. 2021 Apr 9;13(8):1807. doi: 10.3390/cancers13081807

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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G316A ODC1 promoter SNP and its prognostic significance in colorectal and lung cancer. (A) In an online colorectal cancer dataset of 226 primary samples (Sieber dataset), low expression of ODC1 was prognostic of poor outcome (dichotomized at the median). This dataset is available on the R2 platform (R2: Genomics Analysis and Visualization Platform, https://hgserver1.amc.nl/cgi-bin/r2/main.cgi, accessed on 3 August 2020). Patients at risk are not shown as they cannot be generated using this platform. (B) In a cohort of 63 rectal cancer patients, where most patients had a favorable outcome, the AA/AG genotype tended to have a poorer overall outcome than the GG genotype. NS—not significant. (C) In a lung cancer cohort of 524 squamous cell carcinoma patients, low ODC1 expression is associated with worse outcome. Data was obtained from KM Plotter [23]. (D) In a second cohort of 161 squamous cell carcinomas patients, those with AG/AA genotypes tended to have a worse outcome compared with GG genotypes.