Aptamer	Type	Target	Stage	References
ARC183 (HD1)	DNA	Thrombin (exosite 1)	Phase I	[13,14,41,42,43]
NU172	DNA	Thrombin (exosite 1)	Phase II	[15,16,46,47]; NCT00808964
HD22	DNA	Thrombin (exosite 2)	Pre-clinical	[43,49]
HD1-22	DNA	Thrombin exosite 1 and 2)	Pre-clinical	[50]
TBA-F14	DNA	Thrombin (exosite 1)	Pre-clinical	[53]
Tog25	RNA	Thrombin (exosite 2)	Pre-clinical	[56,57,58]
RE31	DNA	Thrombin (exosite 1)	Pre-clinical	[59,60,61]
M08	DNA	Thrombin	Pre-clinical	[46]
ThAD	DNA	Thrombin (exosites 1 and 2)	Pre-clinical	[63,64]
CTBA4T-B1	DNA	Thrombin (exosite 1)	Pre-clinical	[138]
R9D-14T	RNA	Prothrombin and Thrombin (pro-exosite 1 and exosite 1)	Pre-clinical	[65]
Thrombin-03	DNA	Thrombin	Preclinical	[66,67]
RNA11F7t	RNA	Factor Xa	Pre-clinical	[75,76]
RNABA4	RNA	Factor Xa, Prothrombin, and Thrombin	Pre-clinical	[77]
REG1	RNA	Factor IX and IXa (exosite)	Phase III	[10,11,86,87,88,89,90]; NCT00113997, NCT00715455, NCT00932100, NCT01848106
REG2	RNA	Factor IX and IXa	Phase I	[91]
FELIAP	DNA	Factor XIa	Pre-clinical	[99]
11.16	RNA	Factor XIa	Pre-clinical	[100]
12.7	RNA	Factor XIa	Pre-clinical	[100]
16.3	RNA	Factor VIIa	Pre-clinical	[8]
7S-1	RNA	Factor VII	Pre-clinical	[9]
7S-2	RNA	Factor VII	Pre-clinical	[9]
unnamed	DNA	Factor VIII	Pre-clinical	[102]
ARC1779	DNA	Von Willebrand Factor	Phase II	[119,120,121,122,123,124,125,126]; NCT00507338, NCT00694785; NCT00726544; NCT00742612
TAGX-0004	DNA	Von Willebrand Factor	Pre-clinical	[132]
R9.3	RNA	Von Willebrand Factor	Pre-clinical	[133]
R9.14	RNA	Von Willebrand Factor	Pre-clinical	[133]
ARC1172	RNA	Von Willebrand Factor	Pre-clinical	[119,134]
DTRI-031	RNA	Von Willebrand Factor	Pre-clinical	[135]
Rn-DsDsDs-44	DNA	Von Willebrand Factor	Pre-clinical	[136]
ARC15105	RNA	Von Willebrand Factor	Pre-clinical	[127]
BT100	RNA	Von Willebrand Factor	Pre-clinical	[128]
BT200	RNA	Von Willebrand Factor	Pre-clinical	[129,130,131]; (NCT04677803)
R4cXII-1	RNA	Factor XIIa	Pre-clinical	[101]
BAX499	DNA	Tissue Factor Pathway Inhibitor	Phase I	[79,80,81,82,83]
ARC-167	RNA	Activated Protein C	Pre-clinical	[103]
HS02	DNA	Activated Protein C	Pre-clinical	[104,105]
unnamed		Activated Protein C	Pre-clinical	[106]
unnamed	DNA	Activated Protein C	Pre-clinical	[107]
G-NB3	DNA	Activated Protein C	Pre-clinical	[108]