Printability |
Physicochemical properties (surface tension, viscosity, crosslinking) of the ink that allows its spatial and temporal deposition with high precision and accuracy during the printing process. |
Biocompatibility |
The ability of the ink to support normal cellular activity (cell attachments and proliferation) without causing an inflammatory or immune response to the host tissue. |
Biodegradability |
The ideal degradation rate of ink is matching the ability of cells to replace the ink material with their extracellular matrix proteins. Degradation by-products should be harmless and easily metabolized from the host. |
Mechanical property |
Bioinks should provide the required tensile strength, stiffness, and elasticity for mimicking the mechanical properties of native bone tissues and provide the cells with a stable environment for attachment, proliferation, and differentiation. |
Material biomimicry |
Engineering bioink material with specific physiological functions requires mimicking the naturally tissue-specific composition and localization of extracellular matrix components in the human tissue. |