Table 4.
Examples of in vitro cytotoxicity studies on cancer cells.
| Cell Lines Used for Testing | Amygdalin Concentration [mg mL−1] |
Results Observed | Ref. | |
|---|---|---|---|---|
| Bladder cancer | RT 112 UMUC-3 TCCSUP | 1.25–10 | limited proliferative capacity and apoptosis. decrease in cdk4 expression level in RT112 and TCCSUP lines. |
[40] |
| Cervical cancer | HeLa | 1.25–20 | initiation of the cell apoptosis, reduction of Bcl-2 expression level, increase of Bax expression level. | [39] |
| Colon cancer | SNU-C4 | 0.25–5 | reduction of the expression level of many genes associated with following cell functions: growth, apoptosis, transmission. | [53] |
| Breast cancer | MDA-MB-231, MCF-7 | 2.5–80 | reduction of proliferative activity of the cells | [54] |
| MDA-MB-231 | 10 | growth rate of cancer cells was inhibited | [55] | |
| Kidney cancer | Caki-1 A498 KTC-26 xds |
10 | -reduced ability collagen and fibronectin. -reduced cell mobility. |
[47] |