Figure 8.

Significantly different taxa identified at phylum level between SD, HFD and HFD+E treated mice. Differential abundance analyses allowed to identify significantly different taxa between the three study groups. t-Test/ANOVA were used to assess significant results (adjusted p-value < 0.05, specific p-values are detailed in Supplementary Table S2). At phylum level, Actinobacteria (A) and Firmicutes (B) phyla are highly represented in the HFD mice respect to the other two groups. On the contrary, the Bacteroidetes phylum (C) is less abundant in the HFD than in the SD and in the HFD+E mice. Interestingly, the Deferribacteres (D) and the Verrucomicrobia (E) phyla are respectively high and low expressed in the HFD+E mice respect to both SD and HFD.