Table 2.

Statistical analysis results of responses.

Source	Y1		Y2		Y3
	F-Value	p-Value	F-Value	p-Value	F-Value	p-Value
Model	247.23	<0.0001	88.36	<0.0001	122.65	<0.0001
A	64.32	0.0002 *	14.43	0.0090 *	588.76	<0.0001 *
B	1154.38	<0.0001 *	393.75	<0.0001 *	1.60	0.2523
AB	1.38	0.2853	0.3336	0.5846	0.0000	1.0000
A²	1.14	0.3272	3.93	0.0946 *	22.16	0.0033 *
B²	12.75	0.0118 *	32.55	0.0013 *	3.16	0.1257
Lack of Fit	5.34	0.1011	3.51	0.1651	1.74	0.3299
R2 analysis
R²	0.9952		0.9866		0.9903
Adjusted R²	0.9911		0.9754		0.9822
Predicted R²	0.9697		0.9206		0.9499
Adequate Precision	48.0496		28.0624		34.3150

Y₁: particle size; Y₂: In vitro release study; Y₃: hemolysis; *, significant.