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Objectives of the optimization process.
| Independent Variable | Symbol | Level of Variation | ||
|---|---|---|---|---|
| −1 | 0 | +1 | ||
| Surfactant concentration (g) | A | 0.2 | 0.4 | 0.6 |
| Oil concentration (g) | B | 1.5 | 2 | 2.5 |
| Dependent variables | Symbol | Constraints | ||
| Particle size (nm) | Y1 | In range (140–160 nm) | ||
| In vitro drug release (%) | Y2 | In range (55–65%) | ||
| Hemolysis (%) | Y3 | Minimize | ||
