Figure 3.

Histological changes after treatment with TCDD, rapamycin, or both in an IMQ-induced psoriasis mouse model. (A) Hematoxylin and eosin (H&E) staining of representative images from each group (dorsal skin). Bars represent 50 μm. (B) Evaluation of epidermal thickness in dorsal skin. The epidermal thickness was measured from the bottom of the rete ridge to the bottom of the stratum corneum; the mean was calculated from the measurements in four fields at ×100 magnification. Data represent mean ± standard deviation (SD). Statistical significance was determined by one-way repeated measures analysis of variance (ANOVA) with Dunnett’s test. ** p < 0.01; *** p < 0.001. IMQ: imiquimod, Rapa: rapamycin.