Figure 4.

The spleen size and weight of mice from 5 study groups. (A) Spleens were prepared from each mouse and weighed. The spleen shown is from 1 representative experiment with n = 5 per treatment group. (B) The spleens from mice were isolated and weighed, and the spleen weight index was calculated as organ weight (milligram, mg) per gram (g) of mouse body weight. All data are presented as mean ± standard deviation (SD). Statistical differences were determined by one-way repeated measures analysis of variance (ANOVA) with Dunnett’s test. ** p < 0.01; *** p < 0.001. IMQ: imiquimod, Rapa: rapamycin.