Figure 2.

Inhibition of NF-κB-induced inflammation by klotho and SIRT1. NF-κB can be activated by different environmental stimuli as well as endogenous cytokines, such as TNF-α and IL-1. Klotho can inhibit the NF-κB pathway by preventing translocation of NF-κB or inhibiting TLR4-mediated NF-κB activation. SIRT1 prevents the NF-κB pathway by directly inhibiting NF-κB deacetylating NF-κB subunit. NF-κB, nuclear factor kappa light chain enhancer of activated B; TNF-α, Tumor necrosis factor; IL-1, Interleukin 1; TLR4, Toll-like receptor 4, SIRT1, Sirtuin 1.