UVR |
Ultraviolet radiation |
ROS |
Reactive oxygen species |
NADPH |
Nicotinamide adenine dinucleotide phosphate |
HaCaT |
Human epidermal keratinocytes |
IL |
Interleukin |
TNF- α |
Tumor necrosis factor α |
NF-kB |
Nuclear factor kappa light chain enhancer of activated B |
HIF-1a |
Hypoxia-inducible factor 1-alpha |
Nrf-2 |
Nuclear factor erythroid 2-related factor 2 |
AP-1 |
Activator protein 1 |
SC |
Stratum corneum |
TEWL |
Transepidermal water loss |
EGFR |
Epidermal growth factor receptor |
TGFR |
Transforming growth factor receptors |
TLRs |
Toll-like receptors |
TNFR |
TNF-α receptor |
CSF |
Colony stimulating factors |
TGF-α |
Transforming growth factor α |
TGF- β |
Transforming growth factor β |
HMGB1 |
High-mobility group box 1 |
PDGF |
Platelet-derived growth factor |
COX2 |
Cyclooxygenases 2 |
MAP |
Mitogen-activated protein |
PGE2 |
Prostaglandin 2 |
TβRII |
TGF-β type II receptor |
ECM |
Extracellular matrix |
HDFs |
Human dermal fibroblasts |
NHDFs |
Normal human dermal fibroblasts |
HSF2 |
Human skin fibroblasts |
MED |
Minimal erythemal dose |
iNOS |
Inducible nitric oxide synthase |
FGF |
Fibroblast growth factors |
MMPs |
Matrix-degrading metalloproteinases |
MMP-1 |
Collagenase-1 |
MMP-3 |
Stromelysin-1 |
MMP-9 |
Gelatinase B |
COL1A2 |
Type I collagen gene |
SASP |
Senescence-associated secretory phenotype |