Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The molecular mechanism of induction of DNA methylation in human papillomavirus (HPV)--associated head and neck squamous cell carcinoma (HNSCC). Wild-type p53 negatively regulates DNA methyltransferase 1 (DNMT1). HPV E6 oncoprotein cause degradation of p53 and it results in the upregulation of DNMT1 (left). HPV E7 oncoprotein forms a complex with DNMT1 and results in DNMT1 upregulation (middle). MYC is upregulated in HPV-associated HNSCC and recruit DNMT3B (right).
