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. 2021 Apr 10;9(4):801. doi: 10.3390/microorganisms9040801

Figure 3.

Figure 3

Distribution of DNA methylation pattern and biological characteristics in HPV-associated OPSCC. Genome-wide DNA methylation analysis revealed two types of DNA methylation patterns in HPV-associated OPSCC. In high DNA methylation subtype, HPV genome integration (−), episomal HPV (+), high expression of E2/E4/E5, and better prognosis compared to the intermediate DNA methylation subtype and CREBBP mutation (+) were previously reported. In intermediate DNA methylation subtype, HPV genome integration (+), episomal HPV (−), high expression of E6/E7, and worse prognosis compared to the high DNA methylation subtype were reported.