Table 2.

Estimated population parameters of the model and their corresponding RSE.

Estimates of the population parameters
	Parameter	Estimated Value	Unit of Measurement	RSE
Fixed effects	${\tau }^{pop}$	5.62	min	7.5
	$V_I^{pop}$	0.135	L/kg	3.58
	${\alpha }^{pop}$	0.0155	min${}^{-1}$	10.5
	$k_{a1}^{pop}$	0.000134	min${}^{-1}$	36.9
	$k_{a2}^{pop}$	0.0128	min${}^{-1}$	3.43
	$k_e^{pop}$	0.113	min${}^{-1}$	3.33
	${\beta }_{BMI,k_{a2}}$	−0.0865	m${}^2$/kg	13.6
Standard deviations of the random effects	${\omega }_{\tau }$	0.731	dimensionless	8.81
	${\omega }_{V_I}$	0.319	dimensionless	7.17
	${\omega }_{\alpha }$	1.02	dimensionless	7.98
	${\omega }_{k_{a1}}$	1.86	dimensionless	11.8
	${\omega }_{k_{a2}}$	0.322	dimensionless	7.23
	${\omega }_{k_e}$	0.303	dimensionless	6.51
Correlations between random effects	${\rho }_{V_I,k_{a2}}$	0.681	dimensionless	8.19
	${\rho }_{V_I,k_e}$	−0.579	dimensionless	11.1
	${\rho }_{k_{a2},k_e}$	−0.506	dimensionless	14
Error model parameters	$a_1$	1.96	$\mathsf{\mu }$U/mL	8.85
	$b_1$	0.0773	dimensionless	7.66
	$a_2$	2.33	$\mathsf{\mu }$U/mL	5.47
	$b_2$	0.0516	dimensionless	5.79
	$a_3$	2.77	$\mathsf{\mu }$U/mL	5.17
	$b_3$	0.0559	dimensionless	5.76