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. 2021 Apr 9;14(4):348. doi: 10.3390/ph14040348

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biosimilar penetration in Spain over time (adapted from [29]). Biosimilar uptake (%) is calculated as volume of biosimilars over volume of biosimilars plus the originator product (DDDs). * Chondroitin sulfate and the three biosimilars marketed before 2009 (somatropin, filgrastim and epoetin) were excluded to avoid distorting the mean. SOM: somatropin; FIL: filgrastim; EPO: epoetin; FOL: follitropin alfa; INF: infliximab; INS: insuline glargine; ETA: etanercept; CHO: chondroitin sulfate; RIT: rituximab; TRA: trastuzumab; ENO: sodium enoxaparin; ADA: adalimumab; PEG: pegfilgrastim.