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. 2021 Apr 10;22(8):3927. doi: 10.3390/ijms22083927

Figure 2.

Figure 2

Effect of PEA-OXA on neuronal and peripheral nerve morphology. The immunofluorescence staining for β-III tubulin (green) and 4′,6′-diamidino-2-phenylindole (DAPI) (blue) was made on lumbar spinal cord. L-OHP injection changed neuronal morphology (B,E), compared to sham group (A,E), while PEA-OXA significantly preserved neuronal shape (D,E) much more then PEAum (C,E). Scale bar = 20 μm (particle). Hematoxylin and eosin (H&E) was made on sciatic nerve 25 days following L-OHP injection. PEA-OXA significantly preserved sciatic nerve tissue architecture degeneration (I,J), more than PEAum (H,J), compared to L-OHP group (G,J). Data are representative of at least three independent experiments. Values are means ± SEM of 20 animals for each group. One-way ANOVA test; *** p < 0.001 vs. sham; # p < 0.05 vs. L-OHP; ### p < 0.001 vs. L-OHP; ^^ p < 0.01 vs. PEAum.