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. 2021 Apr 11;9(4):412. doi: 10.3390/biomedicines9040412

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Variants in the SARS-CoV-2 proteins. (A) Site 222 (magenta) and Site 614 (red) of spike. Almost all sequences showed a variant (D614G). Site 614 is located at the interface between two subunits. (B) Site 323 (deep salmon) of the NSP12 protein. Many sequences showed a variant (P323L). (C) Site 203 (orange), Site 204 (hot pink), and Site 220 (lime green) of the nucleocapsid protein. The frequencies of variants R203K, G204R, and A220V were high. (D) Site 85 (light pink) of the NSP2 protein. Many sequences showed a variant (T85I). The structures of spike, NSP12, the nucleocapsid protein, and NSP2 were collected from https://zhanglab.ccmb.med.umich.edu/COVID-19/. The protein structural figures were generated by the software PyMOL (http://www.pymol.org/, the accessed date: 16 January 2021).