Figure 3.

Effect of E1-MYC exosome on tumor growth. Mice were injected with either vehicle, Paclitaxel, or two different doses of E1-MYC exosome (1 µg or 5 µg), and tumor volume was recorded thrice weekly. Animals treated with E1-MYC exosome had no difference from vehicle control in terms of tumor growth. Results represent the mean ± SEM, n = 8 for all groups from day 0 to day 16. After day 16, tumor volume in some exosome- or vehicle-treated mice started to exceed 2000 mm³. Euthanizing mice with large tumor volumes reduced the average increase in tumor volume and eventually reduced the tumor volume. At day 28, the vehicle and exosome groups each had only two surviving mice.