Table 4.
Hazard ratios for associations of body weight and cancer risk in participants with Lynch syndrome.
| Setting | Unadjusted Model | Adjusted Model * | ||||||
|---|---|---|---|---|---|---|---|---|
| Cancer Events | Observations | HR (95% CI) | p-Value | Cancer Events | Observations | HR (95% CI) | p-Value | |
| Men | ||||||||
| All cancers | ||||||||
| Longitudinal change | 77 | 610 | 1.02 (1.00–1.03) | 0.048 | 74 | 579 | 1.02 (1.00–1.04) | 0.022 |
| Near-term change | 77 | 185 | 0.99 (0.97–1.00) | 0.345 | 74 | 174 | 0.99 (0.97–1.01) | 0.424 |
| Colorectal cancer | ||||||||
| Longitudinal change | 60 | 610 | 1.02 (1.00–1.03) | 0.023 | 57 | 579 | 1.03 (1.01–1.05) | 0.004 |
| Near-term change | 60 | 185 | 1.00 (0.98–1.01) | 0.695 | 57 | 174 | 1.00 (0.98–1.02) | 0.861 |
| Women | ||||||||
| All cancers | ||||||||
| Longitudinal change | 95 | 758 | 0.99 (0.97–1.00) | 0.290 | 91 | 720 | 1.00 (0.98–1.02) | 0.887 |
| Near-term change | 95 | 221 | 0.98 (0.97–1.00) | 0.059 | 91 | 209 | 0.98 (0.96–1.00) | 0.059 |
| Colorectal cancer | ||||||||
| Longitudinal change | 50 | 758 | 0.99 (0.96–1.01) | 0.258 | 48 | 720 | 0.99 (0.96–1.02) | 0.454 |
| Near-term change | 50 | 221 | 0.98 (0.95–1.00) | 0.106 | 48 | 209 | 0.96 (0.92–0.99) | 0.015 |
* Model adjusted for height, MMR-gene, education, smoking, alcohol consumption, and use of anti-inflammatory drugs. Longitudinal change: longitudinal change in body weight from the age of 20 years until the first cancer diagnosis or censoring. Near-term change: age-stratified change in body weight relative to the body weight at the previous 10-year interval before diagnosis or censoring. p-values statistically significant at <0.05 level. Statistically significant hazard ratios are highlighted in bold. Cancer events: number of occurred cancers. Observations: number of observations across each 10-year interval. HR = hazard ratio. CI = confidence interval.