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In dry eye mice, isorhamnetin reduced expression of pro-inflammatory cytokines in cornea and conjunctiva. (A–F) The mRNA expression level of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and MMP-9 in cornea and conjunctiva. Mice treated with dry eye model for 14 days, and dry eye mice treated with vehicle or isorhamnetin for 10 days while maintaining the dry eye condition (mean ± S.E., n = 4–5). NT, not treated. * p < 0.05, ** p < 0.01, *** p < 0.001.
