Figure 3.

Mitochondrial ROS regulation of cellular processes at a transcriptional level. Antioxidant response, angiogenesis, proliferation, metastasis, and apoptosis are strictly regulated events by an increase in ROS production in the mitochondria (mROS). Indeed, mitochondrial ROS increase promotes the translocation into the nucleus of important factors that possess transcriptional activity, leading to the synthesis of genes related to these main events. In blue, several drugs that target intermediates of different signaling cascades are shown, as reported in Table 1.