Table 1.
Summary of patient and imaging characteristics.
| Case# | Age | Sex | Location | Timing of Liquid Biopsy |
Type of Fluid | CSF Source |
Assessment | Gd-Enhancement | Necrosis | Dissemination |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 7 | F | Pons | At presentation | CSF | LP 1 | H3K27M | + | + | + |
| 2 | 5 | F | Pons | At presentation | CSF | LP 1 | WT 2 | + | + | − |
| 3 | 59 | M | Pons | At presentation | CSF | LP 1 | WT 2 | + | - | − |
| 4 | 9 | M | Pons | At presentation | CSF | LP 1 | WT 2 | ± | − | − |
| At presentation | Plasma | N/A 3 | H3K27M? 4 | ± | − | − | ||||
| 5 | 31 | F | Pons | At presentation | CSF | LP 1 | H3K27M? 4 | ± | − | + |
| 6 | 64 | M | Pons | At presentation | CSF | LP 1 | H3K27M? 4 | − | − | − |
| At recurrence | CSF | LP 1 | H3K27M? 4 | + | ± | − | ||||
| 7 | 23 | M | T 5 | At presentation | CSF | LP 1 | H3K27M? 4 | − | − | − |
| At recurrence | Plasma | N/A 3 | H3K27M? 4 | − | − | − | ||||
| During VP shunt | CSF | Vent tap 6 | H3K27M? 4 | − | − | − | ||||
| 8 | 69 | M | Thal 7 | At presentation | CSF | LP 1 | Unreliable | + | − | − |
| 9 | 7 | F | Pons | At presentation | CSF | LP 1 | Unreliable | + | + | − |
| During VP shunt | CSF | Vent tap 6 | Unreliable | + | + | − | ||||
| 10 | 50 | F | MO 8 | At presentation | CSF | LP 1 | Unreliable | + | − | − |
| 11 | 6 | F | Thal 7 | During VP shunt | CSF | Vent tap 6 | H3K27M | + | − | + |
| At recurrence | Plasma | N/A 3 | H3K27M? 4 | + | − | + | ||||
| 12 | 8 | F | Pons | During treatment | Plasma | N/A 3 | WT 2 | + | − | − |
| At recurrence | Plasma | N/A 3 | H3K27M | + | − | − |
1 Lumbar puncture, 2 Wildtype, 3 Not applicable, 4 H3K27M suspect, 5 Temporal lobe, 6 Ventricular tap, 7 Thalamus, 8 Medulla oblongata.