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. 2021 Apr 10;22(8):3916. doi: 10.3390/ijms22083916

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The Cis+Nira therapy enhances ER stress in 3D cultures of Twist-knockdown CisR OC cells. Western blot analysis of ER stress proteins, GRP78, calnexin, cleaved ATF6 and CHOP in 3D cultures of Twist-knockdown (A) OV90-CisR and (B) SKOV3-CisR OC cells. CisR: cisplatin-resistant; siRNA: small interfering RNA; siNC: non-targeting negative control, siRNA; siTwist: Twist siRNA; DMSO: dimethyl sulfoxide, Cis: cisplatin; Nira; niraparib. Values were represented as mean ± SD. # p < 0.05, compared with siNC group; * p < 0.05, compared with the siTwist (DMSO) group.