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. 2021 Apr 10;22(8):3916. doi: 10.3390/ijms22083916

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The combination therapy efficiently activated mitochondrial-dependent apoptotic pathway in Twist-knockdown CisR OC cells. (A) Western blot analysis of Bax, Bcl-2 and cytochrome C in 3D cultured of Twist knockdown OC cells. (B) The ratio of cytochrome C in cytosolic fraction to that in mitochondria fraction. (C) H&E staining for morphology evaluation and immunohistochemistry of the cell proliferation marker, ki-67 and apoptosis marker, cleaved caspase-3 immunoreactivity prediction (Magnification, 40×, scale bar 20 µm). CisR: cisplatin-resistant; siRNA: small interfering RNA; siNC: non-targeting negative control, siRNA; siTwist: Twist siRNA; DMSO: dimethyl sulfoxide, Cis: cisplatin; Nira; Niraparib. Values were represented as mean ± SD. # p < 0.05, compared with siNC group; * p < 0.05, compared with the siTwist (DMSO) group.