Table 2.
Factors associated with in-hospital mortality in critically ill COVID-19 patients.
| Univariable Analysis Hazard Ratio (IC 95%) |
p-Value | Multivariable Analysis Hazard Ratio (IC 95%) |
p-Value | |
|---|---|---|---|---|
| Age | 1.1 (1.1–1.2) | 0.01 | 1.06 (0.99–1.14) | 0.11 |
| Male sex | 0.4 (0.2–0.81) | <0.001 | 0.50 (0.21–1.05) | 0.64 |
| BMI 1 | 0.99 (0.93–1.1) | 0.68 | ||
| Smokers | 0.5 (0.068–3.6) | 0.49 | ||
| Charlson Index | 1.3 (1.2–1.4) | <0.001 | 4.46 (0.26–75.55) | 0.30 |
| SAPS II 2 | 10 (1.7–58) | 0.01 | 1.06 (0.08–13.36) | 0.96 |
| PaO2/FiO2 ≤100 | 3.4 (1.7–6.8) | <0.001 | 4.65 (1.81–11.97) | 0.001 |
| Invasive mechanical ventilation | 1.8 (0.76–4.1) | 0.19 | 2.88 (0.76–10.97) | 0.12 |
| Norepinephrine (>1 µg/kg/min) | 2.1 (1–4.1) | 0.04 | 1.08 (0.30–2.84) | 0.90 |
| Renal replacement therapy | 2.9 (1.4–6.2) | 0.005 | 1.58 (0.58–4.31) | 0.37 |
| Creatininemia (log10) | 8.5 (2.3–32) | 0.002 | 1.45 (0.20–10.73) | 0.71 |
| Hs-cTnT 3 (log10) | 4.3 (2.5–7.2) | <0.001 | 4.96 (1.92–12.86) | <0.001 |
| CRP 4 (log10) | 0.83 (0.37–1.9) | 0.65 | ||
| PCT 5 (log10) | 1.7 (1–2.9) | 0.05 | 1.60 (0.60–4.25) | 0.3 |
| Lactatemia (log10) | 1.8 (0.21–16) | 0.58 | ||
| D-dimer (log10) | 2.4 (0.81–6.9) | 0.12 | 1.21 (0.17–3.95) | 0.8 |
1 BMI, body mass index; 2 SAPS II, Simplified Acute Physiology Score II; 3 hs-cTnT, high-sensitive cardiac troponin T; 4 CRP, C reactive protein; 5 PCT, procalcitonin.