Table 3.
Percentage of PS amplitude values of BST and LTP recorded in the CA1 region of hippocampal slices from the control group and groups treated with NAA and sCT at different times.
| TIME (min) | CTRL (PS% Amplitude) |
sCT Monomers (PS% Amplitude) |
sCT PFOs (PS% Amplitude) |
NAA 0.05 mIU/mL + sCT PFOs (PS% Amplitude) |
NAA 0.5 mIU/mL + sCT PFOs (PS% Amplitude) |
SIGNIFICANCE between Groups at Different Times |
|---|---|---|---|---|---|---|
| 1 | 104.7 ± 13.9 | 100.3 ± 14.4 | 99.9 ± 9.7 | 99.6 ± 12.9 | 99.3 ± 18.0 | no significance |
| 36 | 102.0 ± 18.7 | 108.6 ± 21.7 | 105.7 ± 15.8 | 117.8 ± 12.9 | 156.2 ± 44.6 | no significance |
| 76 | 104.2 ± 18.6 | 128.7 ± 25.8 | 87.2 ± 16.9 | 124.4 ± 11.3 | 184.5 ± 52.8 | CTRL vs. NAA 0.5 mIU/mL + sCT PFOs, *** p < 0.001 |
| 86 | 356.8 ± 28.6 | 297.3 ± 19.1 | 207.5 ± 38.6 | 216.1 ± 29.1 | 378.3 ± 113.8 | CTRL vs. sCT PFOs and NAA 0.05 mIU/mL + sCT PFOs, **** p < 0.0001 |
| 136 | 226.4 ± 32.7 | 201.0 ± 12.7 | 105.5 ± 20.1 | 157.6 ± 22.9 | 313.9 ± 79.8 | CTRL vs. sCT PFOs, **** p < 0.0001; CTRL vs. NAA 0.05 mIU/mL + sCT PFOs, ** p < 0.01; CTRL vs. NAA 0.5 mIU/mL + sCT PFOs, *** p < 0.001 |
PS: Population Spikes; BST: Basal Synaptic Transmission; LTP: Long-Term Potentiation; NAA: Neuraminidase; sCT: salmon Calcitonin; CTRL: control group; sCT PFOs: Prefibrillar Oligomers of salmon Calcitonin; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001.