Table 1.
Biodistribution data for [18F]1 in athymic mice bearing HepG2 xenografts in the flank area 1.
| Organ | 30 min | 1 h | 1 h Block 2 | 2 h |
|---|---|---|---|---|
| Lungs | 3.9 ± 0.6 | 3.8 ± 0.7 | 3.5 ± 0.8 | 2.1 ± 0.8 |
| Heart | 4.1 ± 0.7 | 4.0 ± 0.7 | 3.7 ± 0.3 | 3.3 ± 0.9 |
| Kidneys | 3.7 ± 0.8 | 3.3 ± 0.6 | 3.8 ± 0.4 | 2.4 ± 0.6 |
| Liver | 3.2 ± 0.5 | 2.8 ± 0.4 | 3.3 ± 0.6 | 2.4 ± 0.5 |
| Spleen | 3.3 ± 0.4 | 2.7 ± 0.7 | 3.0 ± 0.6 | 2.1 ± 0.4 |
| Stomach | 5.1 ± 2.0 | 2.7 ± 0.8 | 1.6 ± 1.2 | 2.1 ± 0.7 |
| Small Intestine | 3.9 ± 1.0 | 4.0 ± 0.7 | 4.1 ± 0.3 | 3.0 ± 0.5 |
| Large Intestine | 6.1 ± 1.7 | 7.7 ± 1.8 | 3.4 ± 1.4 * | 7.1 ± 2.9 |
| Skin | 3.7 ± 0.7 | 3.4 ± 0.5 | 3.0 ± 0.7 | 3.1 ± 0.4 |
| Muscle | 3.5 ± 0.8 | 2.6 ± 0.6 | 3.3 ± 0.4 | 2.6 ± 0.7 |
| Blood | 4.2 ± 0.6 | 4.1 ± 0.6 | 2.7 ± 0.9 * | 3.3 ± 0.8 |
| Bone | 3.1 ± 0.6 | 3.6 ± 1.0 | 1.9 ± 0.4 * | 5.4 ± 0.8 |
| Brain | 2.9 ± 0.8 | 2.6 ± 0.8 | 3.3 ± 0.5 | 2.0 ± 0.7 |
| Tumor | 3.3 ± 0.3 | 3.0 ± 0.7 | 3.2 ± 0.7 | 3.0 ± 0.8 |
1 Data presented as %ID/g; 2 Blocking group (n = 4) received SP-141 (1.2 mg) i.p. 30 min before i.v. [18F]1. * p < 0.05 vs. 1 h non-blocking group.