Figure 2.

Influence of extracellular acidification on melanoma progression. Detailed descriptions can be found in the text. Abbreviations: NHE, Na/H exchanger; MCT, monocarboxylate transporters; PPP, pentose phosphate pathway; CA, carbonic anhydrase; N-cad, N-cadherin; NF-κB, nuclear factor-kappa B; E-cad, E-cadherin; KLF4, Krüppel-like factor 4; OCT4, octamer-binding transcription factor 4; SOX2, SRY-box transcription factor 2; ALDH, aldehyde dehydrogenase; MMP, matrix metalloproteinase; MITF, microphthalmia-associated transcription factor; VEGF, vascular endothelial growth factor; IL-8, interleukin 8; EMT, epithelial-to-mesenchymal transition.