Table 2.
Association of gene variant panel with the risk of obesity.
| Gene | SNP ID | Alleles | Non-Obese | Obese | Genotypes | Non-Obese | Obese | Model | Adjusted OR (95%CI) | p-Value |
|---|---|---|---|---|---|---|---|---|---|---|
|
GSTM1
|
rs1056806 | C allele | 416 (93) | 270 (88) | C/C | 195 (87) | 119 (78) | Heterozygote | 2.02 (1.15–3.55) | 0.015 * |
| T allele | 32 (7) | 36 (12) | C/T | 26 (12) | 32 (21) | Homozygote | 1.09 (0.18–6.63) | 0.05 | ||
| p-value | 0.22 | T/T | 3 (1) | 2 (1) | Dominant | 1.92 (1.11–3.31) | 0.019 * | |||
| p-value | 0.039 * | Recessive | 0.98 (0.16–5.91) | 0.98 | ||||||
|
GSTT1
|
rs1111875 | A allele | 259 (76) | 159 (75) | A/A | 96 (56) | 61 (58) | Heterozygote | 0.87 (0.52–1.45) | 0.42 |
| C allele | 81 (24) | 53 (25) | A/C | 67 (39) | 37 (35) | Homozygote | 1.80 (0.62–5.21) | 0.45 | ||
| p-value | 0.86 | C/C | 7 (4) | 8 (8) | Dominant | 0.96 (0.59–1.56) | 0.86 | |||
| p-value | 0.41 | Recessive | 1.90 (0.67–5.40) | 0.23 | ||||||
|
GSTP1
|
rs1695 | A allele | 221 (65) | 133 (62) | A/A | 73 (43) | 45 (42 | Heterozygote | 0.93 (0.55–1.58) | 0.46 |
| G allele | 117 (35) | 81 (38) | A/G | 75 (44) | 43 (40) | Homozygote | 1.47 (0.71–3.03) | 0.49 | ||
| p-value | 0.65 | G/G | 21 (12) | 19 (18) | Dominant | 1.05 (0.64–1.71) | 0.85 | |||
| p-value | 0.45 | Recessive | 1.52 (0.78–2.99) | 0.22 | ||||||
|
MGST3
|
rs7744724 | C allele | 339 (96) | 214 (98) | C/C | 165 (93) | 105 (96) | Heterozygote | 0.70 (0.21–2.33) | 0.20 |
| T allele | 15 (4) | 4 (2) | C/T | 9 (5) | 4 (4) | Homozygote | 0.00 (0.00–NA) | 0.57 | ||
| p-value | 0.11 | T/T | 3 (2) | 0 (0) | Dominant | 0.52 (0.16–1.67) | 0.25 | |||
| p-value | 0.33 | Recessive | 0.00 (0.00–NA) | 0.09 | ||||||
|
SOD1
|
rs2234694 | A allele | 338 (97) | 209 (100) | A/A | 166 (95) | 104 (99) | Heterozygote | 0.27 (0.03–2.24) | 0.15 |
| C allele | 10 (3) | 1 (0) | A/C | 6 (3) | 1 (1) | Homozygote | 0.00 (0.00–NA) | 0.17 | ||
| p-value | 0.048 * | C/C | 2 (1) | 0 (0) | Dominant | 0.20 (0.02–1.62) | 0.07 | |||
| p-value | 0.23 | Recessive | 0.00 (0.00–NA) | 0.17 | ||||||
|
SOD2
|
rs4880 | A allele | 191 (57) | 102 (48) | A/A | 58 (35) | 26 (25) | Heterozygote | 1.49 (0.83–2.67) | 0.13 |
| G allele | 143 (43) | 110 (52) | A/G | 75 (45) | 50 (47) | Homozygote | 1.97 (1.00–3.86) | 0.045 * | ||
| p-value | 0.038 * | G/G | 34 (20) | 30 (28) | Dominant | 1.64 (0.95–2.82) | 0.07 | |||
| p-value | 0.13 | Recessive | 1.54 (0.88–2.72) | 0.13 | ||||||
|
SOD3
|
rs2536512 | A allele | 170 (51) | 118 (56) | A/A | 39 (23) | 38 (36) | Heterozygote | 0.47 (0.26–0.83) | 0.033 * |
| G allele | 166 (49) | 92 (44) | A/G | 92 (55) | 42 (40) | Homozygote | 0.69 (0.35–1.36) | 0.07 | ||
| p-value | <0.001 * | G/G | 37 (22) | 25 (24) | Dominant | 0.53 (0.31–0.91) | 0.021 * | |||
| p-value | 0.033 * | Recessive | 1.11 (0.62–1.97) | 0.73 | ||||||
| CAT | rs7943316 | A allele | 116 (47) | 52 (40) | A/A | 34 (28) | 13 (20) | Heterozygote | 0.85 (0.43–1.69) | 0.46 |
| T allele | 130 (53) | 78 (60) | T/A | 48 (39) | 26 (40) | Homozygote | 0.60 (0.27–1.35) | 0.90 | ||
| p-value | 0.18 | T/T | 41 (33) | 26 (40) | Dominant | 0.75 (0.40–1.40) | 0.37 | |||
| p-value | 0.46 | Recessive | 0.65 (0.32–1.35) | 0.24 | ||||||
|
GPX1
|
rs1800668 | A allele | 83 (19) | 72 (25) | A/A | 9 (4) | 15 (10) | Heterozygote | 1.03 (0.64–1.65) | 0.77 |
| G allele | 345 (81) | 218 (75) | G/A | 65 (30) | 42 (29) | Homozygote | 2.65 (1.11–6.32) | 0.048 * | ||
| p-value | 0.041 * (M-H) | G/G | 140 (65) | 88 (61) | Dominant | 1.23 (0.79–1.90) | 0.36 | |||
| p-value | 0.07 | Recessive | 2.63 (1.12–6.18) | 0.024 * | ||||||
|
GPX4
|
rs713041 | C allele | 176 (52) | 111 (53) | C/C | 42 (25) | 27 (26) | Heterozygote | 0.96 (0.54–1.73) | 0.97 |
| T allele | 160 (48) | 97 (47) | C/T | 92 (55) | 57 (55) | Homozygote | 0.92 (0.44–1.91) | 0.99 | ||
| p-value | 0.82 | T/T | 34 (20) | 20 (19) | Dominant | 0.95 (0.54–1.67) | 0.86 | |||
| p-value | 0.48 | Recessive | 0.94 (0.51–1.74) | 0.84 | ||||||
|
NOS3
|
rs1799983 | G allele | 254 (75) | 176 (83) | G/G | 97 (57) | 73 (69) | Heterozygote | 0.66 (0.39–1.13) | 0.09 |
| T allele | 84 (25) | 36 (17) | T/G | 60 (36) | 30 (28) | Homozygote | 0.33 (0.09–1.22) | 0.21 | ||
| p-value | 0.029 * | T/T | 12 (7) | 3 (3) | Dominant | 0.61 (0.37–1.02) | 0.06 | |||
| p-value | 0.10 | Recessive | 0.38 (0.10–1.38) | 0.11 | ||||||
|
NOS2
|
rs2297518 | A allele | 123 (36) | 82 (38) | A/A | 23 (13) | 13 (12) | Heterozygote | 1.34 (0.80–2.26) | 0.51 |
| G allele | 221 (64) | 134 (62) | A/G | 77 (45) | 56 (52) | Homozygote | 1.04 (0.48-2.29) | 0.25 | ||
| p-value | 0.59 | G/G | 72 (42) | 39 (36) | Dominant | 1.27 (0.78-2.09) | 0.34 | |||
| p-value | 0.51 | Recessive | 0.89 (0.43-1.83) | 0.74 | ||||||
Binary regression analysis was performed to estimate the adjusted risk of obesity in each genotype’s presence according to various genetic association models. The odds ratio (OR) and 95% confidence interval (CI) for each model are shown. The adjustment was performed by age and sex. MH: Mantel–Haenszel chi-square test. (*) Indicates significance at p-value < 0.05.