Table 2.
Concentrations of donepezil and 6-O-desmethyldonepezil. Concentrations of donepezil and 6-O-desmethyldonepezil (O-DNP) in porcine plasma and selected organs/body fluids collected 24 h after the last intragastric administration of 10 mg donepezil (on day 8) with preceding 7-day administration of donepezil (5 mg per day) and dextran sodium sulfate (10 g per day).
| Tissue | Donepezil (nM) | Ratio | O-DNP (nM) | Ratio |
|---|---|---|---|---|
| Mean ± SEM | Mean ± SEM | |||
| plasma | 1.77 ± 0.35 | 1.00 | 0.43 ± 0.10 | 1.00 |
| stomach | 72.16 ± 15.89 | 40.76 | 1.45 ± 0.22 | 3.37 |
| proximal jejunum | 370.53 ± 112.94 | 209.34 | 17.25 ± 4.02 | 40.12 |
| mid jejunum | 104.61 ± 68.27 | 59.10 | 4.33 ± 0.88 | 10.07 |
| ileum | 14.42 ± 1.30 | 8.15 | 3.96 ± 1.19 | 9.21 |
| colon | 14.61 ± 1.54 | 8.25 | 6.60 ± 4.69 | 15.35 |
| muscle | 6.26 ± 0.29 | 3.54 | 9.91 ± 0.50 | 23.05 |
| fat | 5.68 ± 0.74 | 3.20 | 6.46 ± 2.25 | 15.02 |
| skin | 5.22 ± 0.68 | 2.95 | 7.88 ± 0.94 | 18.33 |
| spleen | 15.34 ± 1.74 | 8.66 | 3.26 ± 0.27 | 7.58 |
| liver | 127.14 ± 8.57 | 71.83 | 44.33 ± 5.31 | 103.09 |
| kidney | 25.56 ± 3.03 | 14.44 | 21.67 ± 3.44 | 50.40 |
| heart | 4.38 ± 0.21 | 2.48 | 1.00 ± 0.17 | 2.33 |
| lung | 20.73 ± 1.13 | 11.71 | 3.73 ± 0.43 | 8.67 |
| medulla | 7.99 ± 1.22 | 4.51 | 8.36 ± 1.68 | 19.44 |
| medulla oblongata | 7.02 ± 0.64 | 3.97 | 7.03 ± 0.97 | 16.35 |
| front lobe | 5.21 ± 0.32 | 2.94 | 3.95 ± 0.25 | 9.19 |
| cerebellum | 4.73 ± 0.20 | 2.67 | 3.60 ± 0.15 | 8.37 |
| pituitary gland | 13.12 ± 0.99 | 7.41 | 8.40 ± 0.48 | 19.54 |
| hippocampus | 5.22 ± 0.44 | 2.95 | 4.31 ± 0.56 | 10.02 |
| diencephalon | 4.58 ± 0.37 | 2.58 | 3.82 ± 0.20 | 8.88 |
| urine | 45.88 ± 9.68 | 25.92 | 62.90 ± 12.48 | 146.28 |
| bile | 601.63 ± 112.12 | 339.90 | 444.35 ± 132.62 | 1033.37 |
O-DNP: 6-O-desmethyldonepezil; SEM: standard error of the mean.