Figure 3.

Effects of DMF02 on melanosome degradation. B16F0 melanoma cells (A) or HaCaT cells (C) were stained for premelanosome protein (PMEL). Intensity of PMEL was represented as a relative fold. B16F0 melanoma cells (B) or HaCaT cells (D) were treated with α-MSH or isolated melanosomes in the absence or presence of DMF02. Scale bar 20 μm. Data are mean ± SEM. p < 0.05 vs. UVB plus vehicle alone. # p < 0.05 vs. medium alone-added group. ** p < 0.05 vs. α-MSH-stimulated group or melanosome-treated group. The difference was determined using the Student’s t-test.