Table 3.
Neonates with a low risk of early-onset sepsis and antibiotic treatments at baseline and in the intervention period.
| Variables | Baseline (n = 26) |
Intervention (n = 34) |
p |
|---|---|---|---|
| Male gender, n (%) | 12 (46) | 18 (53) | 0.79 |
| Gestational age, weeks, median (IQR) | 31 (29–32) | 30 (29–31) | 0.04 |
| Birth weight, g, median (IQR) | 1320 (1076–1456) | 1220 (990–1445) | 0.32 |
| Apgar score at the 5th min, median (IQR) | 9 (7–10) | 8 (7–9) | 0.05 |
| CRIB score, median (IQR) | 1 (0–1) | 1 (0–4) | 0.60 |
| Twins, n (%) | 4 (15) | 5 (15) | 0.77 |
| Maternal fever in labor (> 38 °C), n (%) | 0 (0) | 1 (3) | 0.89 |
| IAP, n (%) No Adequate Inadequate |
25 (96) 0 (0) 1 (4) |
27 (79) 6 (18) 1 (3) |
0.04 |
| Prenatal steroids, n (%) | 22 (85) | 31 (91) | 0.43 |
| Median length of stay, days (IQR) | 47 (38–57) | 46 (42–57) | 0.99 |
| First antibiotic treatment Total, n (%) 48-h rule-out course, n (%) § Median duration, hours (IQR) § |
13 (50) 0 (0) 144 (96–168) |
16 (48) 14 (88) 72 (48–72) |
0.97 <0.01 <0.01 |
| Days of therapy Total Median (IQR) |
233 2 (0–15) |
190 0 (0–6) |
<0.01 <0.01 |
| Days of therapy/1000 patient-days | 194 | 113 | <0.01 |
CRIB, clinical risk index for babies. IAP, intrapartum antibiotic prophylaxis. IQR, interquartile range. Indications of intrapartum antibiotic prophylaxis are: maternal group B streptococcus colonization, preterm birth, group B streptococcus bacteriuria identified during the current pregnancy, previous infant with group B streptococcus infection, membrane rupture ≥ 18 h, maternal temperature ≥ 38 °C during labor. § percent rates and median duration were calculated only on neonates who were given antibiotics.