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. 2021 Apr 13;10(4):881. doi: 10.3390/cells10040881

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Actions of current therapeutics and FPR2 agonists in the context of cardiovascular disease in rheumatoid arthritis patients. The mechanisms of action of current therapeutics in RA patients are indicated and colour coded in relation to their cardiovascular disease (CVD) risk with green being protective and red detrimental. Actions of pro-resolving mediators LXA4 (lipoxin A4), resolvin D1 (RvD1), annexin A1 (Anx-A1), and the synthetic agonist compound 17b (Cmpd17b) mediated through the G-protein coupled receptor FPR2 are also indicated. The lipid-lowering medications statins are also included, and their impact on C-reactive protein (CRP) is indicated, as is their role in the generation of 13-series resolvins (RvT) and 15-epi-LXA4.